The University of Copenhagen is looking for an interested candidate for the position of Postdoctoral Fellowship who has experience in DNA Technology and protein expression purification and charaterization.
- Obtained a PhD degree within biochemistry, biotechnology, molecular biology, structural biology or related fields.
- Experience with recombinant DNA technology and protein expression, purification and characterization
- Fluency in English and excellent communication and interpersonal skills
|Employer||University of Copenhagen|
- The postdoctoral projects will focus on the development of novel small molecules against proteins in the brain. The proteins are involved in key pathological processes like oxidative stress and excitotoxicity, which play a fundamental role in CNS diseases such as ischemic stroke and neurodegeneration. In the search for small molecule inhibitors, essential knowledge of the ‘ligandability’ of the proteins is attained, and new inhibitors can serve as valuable tools for further pharmacological studies. Thus, this project can contribute significantly to the discovery of new therapeutic principles against challenging targets and CNS diseases.
- The overall goal of the postdoc projects is to develop and apply the technological tools that will allow us to identify, characterize and optimize novel fragments (small and simple substructures of druglike compounds) into potent and bioactive inhibitors. Specifically, the key tasks will be to express and purify proteins, setup biochemical and biophysical assays (e.g. NMR, SPR, ITC) for characterizing protein function and performing screenings of our in-house fragment library, and assist in the optimization process and biostructural studies of fragment hits.
- manage and carry through your research project
- The 2 postdoc positions are financed by the Lundbeck Foundation Fellowship starting grant.
- write scientific articles
- participate in national and international congresses and scientific meetings
Deadline: 30 Sep 2015
The Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences at the University of Copenhagen is offering two temporary postdoctoral positions within Fragment-based drug discovery against CNS protein targets. The positions are for two years from January 18th, 2016 or as soon as possible thereafter with the possibility of extension.